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Viktiga publiceringar

Konceptet thromboinflammation

  • Moberg, L., Johansson, H., Luknius, A, Berne, C., Foss, A., Källen, R., Østraat, Ø, Salmela, K., Tibell, A., Tufveson, G., Elgue, G., Ekdahl, K N., Larsson, R., Korsgren, O., Nilsson, B. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002; 360:2039-2045


  • Özmen, L., Ekdahl, K N. Elgue, G., Larsson, R., Korsgren, O., Nilsson, B. Inhibition of thrombin with Melagatran abrogates instant blood mediated islet reaction (IBMIR) in vitro: Possible application in clinical allogeneic pacreatic islet transplantation. Diabetes 2002; 51: 1779-1784


  • Goto M, Tjernberg J, Dufrane D, Elgue G, Brandhorst D, Ekdahl, K N. Brandhorst H, Wennberg L, Kurokawa Y, Satomi S, Lambris JD, Gianello P, Korsgren O, Nilsson B. Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation 2008; 15(4): 225-234


  • Nilsson, B., Ekdahl, K N., Korsgren, O. Control of IBMIR (Instant Blood-Mediated Inflammatory Reaction) to improve islets of Langerhans engraftment. Current Opinion in Organ Transplantation, 2011;16(6):620-6


  • Biglarnia, A-R, Nilsson, B, Ekdahl, K N., Tufveson, G, Nilsson, T, Wadström, J Desenzitation Protocol with Antigen-Specific Immunoadsorption Interferes with Complement in ABO Incompatible Renal Transplantation. Transplantation 2012; 93(1):87-92


  • Nilsson, B., Teramura, Y, Ekdahl, K N. The role and regulation of complement activation as part of the thromboinflammation elicited in cell therapies. Mol Immunol 2014; 61(2):185-190


  • Teramura, Y, Asif, S, Ekdahl, KN, Nilsson, B. Cell surface engineering for regulation of immune reactions in cell therapy. In ”Immune Responses to Biosurfaces” Adv Exp Med Biol. 2015;865:189-209.


  • Biglarnia, A-R, Ekdahl, KN, Nilsson, B. Complement interception across humoral incompatibility in solid organ transplantation – a clinical perspective. In ”Immune Responses to Biosurfaces” Adv Exp Med Biol. 2015;865:211-33.


  • Ekdahl, KN, Teramura, Y, Hamad, OA, Asif, S, Dürhkop, C, Fromell, K, Gustafson, E, Hong, J, Kozarcanin, H, Magnusson, PU, Huber-Lang, M, Garred, P, Nilsson, B. Dangerous liaisons: Complement, coagulation, and kallikrein/kinin crosstalk act as a linchpin in the events leading to thromboinflammation. Immunological Reviews 2016 Nov;274(1):245-269.


  • Ekdahl, KN, Soveri, I, Hilborn, J, Fellström, B, Nilsson, B . Cardiovascular disease in haemodialysis : role of the intravascular innate immune system. Nat Rev Nephrol. 2017 May;13(5):285-296.


  • Biglarnia, A-R, Huber-Lang, M, Mohlin, C, Ekdahl, KN, Nilsson, B. The multifaceted role of complement in kidney transplantation. Nat Rev Nephrol 2018 Dec;14(12):767-781.

Karakterisera produkten och andra cellbindande material

  • Teramura, Y, Iwata, H. Cell surface modification with polymers for biomedical studies, Soft Matter. 6 (6), 1081-1091.


  • Teramura Y, Kaneda Y, Iwata H. Islet-encapsulation in ultra-thin layer-by-layer membranes of poly(vinyl alcohol) anchored to poly(ethylene glycol)-lipids in the cell membrane. Biomaterials. 2007 Nov;28(32):4818-25. Epub 2007 Aug 14.


  • Teramura Y, Iwata H. Surface modification of islets with PEG lipid for improvement of graft survival in intraportaltransplantation. Transplantation. 2009 Sep 15;88(5):624-30.


  • Nilsson, PH, Ekdahl, K N. Magnusson, PU, Ricklin, D, Iwata, H, Lambris, JD, Hong, J, Nilsson, B, Teramura, Y. Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating. Biomaterials 2013;34(4):985-994


  • Asif, S, Ekdahl, KN, Fromell, K, Gustafson, E, Le Blanc, K, Nilsson, B, Teramura, Y. Heparinization of cell surfaces with short peptide-conjugated PEG-lipid regulates thromboinflammation in transplantation of human MSCs and hepatocytes. Acta Biomater. 2016 35. 194-205


  • Teramura, Y, Asif, S, Ekdahl, KN, Gustafson, E, Nilsson, B. Cell adhesion induced using surface modification with cell-penetrating peptide-conjugated PEG-lipid: A new cell glue for 3D cell-based structures. ACS Appl Mater Interfaces. 2017 9(1):244-254.


  • Noiri, M, Asawa, K, Okada, N, Kodama, T, Murayama, Y, Inoue, Y, Ishihara, K, , Ekdahl, KN, Nilsson, B, Teramura, Y. Cell surface engineering of human MSC with short peptide-PEG-lipid for homing to activated endothelium to improve therapeutic effects in stroke. J Biomed Mater Res A. 2019 Aug;107(8):1779-1792.


  • Asawa, K, Ishihara, K, Ekdahl, K.N, Nilsson, B, Teramura, Y. Cell surface functionalization with heparin-conjugated lipid to suppress blood activation. Advanced Functional Materials 31 (11), 2008167

Alireza Biglarnias viktiga publikationer relaterat till iCoat’s forskning

  • Berglund D, Karlsson M, Biglarnia AR, Lorant T, Tufveson G, Korsgren O, Carlsson B. Obtaining regulatory T cells from uraemic patients awaiting kidney transplantation for use in clinical trials. Clin Exp Immunol. 2013 Aug;173(2):310-22.


  • Berglund D, Bergqvist D, Lundqvist E, Magnusson A, Sedigh A, Bäckman L, Biglarnia AR. Vascular reconstruction using allogeneic homografts in a renal transplant patient with pseudoaneurysm and infected vascular prosthesis. Transplantation. 2012 Feb 27;93(4):e15-6.


  • Berglund D, Bengtsson M, Biglarnia A, Berglund E, Yamamoto S, von Zur-Mühlen B, Lorant T, Tufveson G. Screening of mortality in transplant patients using an assay for immune function. Transpl Immunol. 2011 May;24(4):246-50.

Kristina N Ekdahls viktiga publikationer relaterat till iCoat’s forskning

  • Ekdahl, KN, Huang, S, Nilsson, B, Teramura, Y. Complement inhibition in biomaterial- and biosurface-induced thromboinflammation. Seminars in Immunology, 2016; 28(3); 268-277


  • Harboe, M, Johnson, C, Nymo, S, Ekholt, K, Schjalm, C, Lindstad, JK, Pharo, A, Hellerud, BC, Ekdahl, KN , Mollnes, TE, Nilsson, PH. Properdin binding to complement activating surfaces depends on initial C3b deposition. PNAS 2017 Jan 24;114(4):E534-E539.


  • Eriksson, O, Mohlin, C, Nilsson, B, Ekdahl, KN. Platelets and Immune Responses During Thromboinflammation. The human platelet as an innate immunity cell: Interaction between activated platelets and the complement system. Front Immunol. 2019 Jul 10;10:1590. doi: 10.3389/fimmu.2019.01590. eCollection 2019.

Marianne Jensen-Waerns viktiga publikationer relaterat till iCoat’s forskning

  • Gröndahl, G., Johannisson, A. Jensen-Waern, M., Ekdahl, K N. Opsonization of yeast cells with equine C3 and IgG. Vet Immunol Immunopathol 2001;6425:1-15


  • Rydén A, Manell E, Biglarnia A, Hedenqvist P, Strandberg G, Ley C, Hansson K, Nyman G, Jensen-Waern M. Nursing and training of pigs used in renal transplantation studies. Lab Anim. 2019 Oct 24:23677219879169.


  • Hedenqvist P, Trbakov A, Mellgren T, Öhman-Mägi C, Hammarström Johansson P, Manell E, Ekman S, Ley C, Jensen-Waern M, Thor A .The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits. PloS One 2020; May 21;15(5):e0233530. doi: 10.1371/journal.pone.0233530. eCollection 2020.PMID: 32437406


  • Manell E, Puuvuori E, Svensson A, Velykian I, Hedenqvist P, Hulsart G, Holst J, Jensen-Waern M, Eriksson O. ”Exploring the GLP-1 – GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo   autoradiography. BMJ Open Diabetes Research & Care, 2021; Apr;9(1):e002083. doi: 10.1136/bmjdrc-2020-002083.PMID: 33903116

Bo Nilssons viktiga publikationer relaterat till iCoat’s forskning

  • Janssen, B J C, Huizinga, E G, Raaijmakers, H C A, Roos, A, Daha, M R, Ekdahl, K N. Nilsson B , Gros, P Structures of complement component C3 provide insights into the function and evolution of immunity. Nature 2005;437; 505-511


  • Dührkop, C, Leneweit, G, Heyder, C, Fromell, K, Edwards, K, Ekdahl, KN, Nilsson, B. Development and characterization of an innovative heparin coating to stabilize and protect liposomes against adverse immune reactions. Colloids and Surfaces B: Biointerfaces 2016 Feb 8;141:576-583


  • Fromell, K, Adler, A, Åman, A, Manivel, VA, Huang, S, Dührkop, C, Sandholm, K, Ekdahl, KN, Nilsson, B. Assessement of the role of C3(H2O) in the alternative pathway. 2020. Frontiers in immunology in press

Yuji Teramura viktiga publikationer relaterat till iCoat’s forskning

  • Teramura Y, Iwata H. Bioartificial pancreas microencapsulation and conformal coating of islet of Langerhans Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):827-40.


  • Teramura Y, Chen H, Kawamoto T, Iwata H. Control of cell attachment through polyDNA hybridization. Biomaterials. 2010 Mar;31(8):2229-35.


  • Teramura Y, Iwata H. Improvement of graft survival by surface modification with poly(ethylene glycol)-lipid and urokinase in intraportal islet transplantation. Transplantation. 2011 Feb 15;91(3):271-8.


  • Teramura, Y. Ekdahl, K.N, Nilsson, B, Fromell, K, Ishihara, K. Potential of cell surface engineering with biocompatible polymers for biomedical applications. Langmuir. 2020 Sep 36 (41), 12088-12106.

David Berglund viktiga publikationer relaterat till iCoat’s forskning

  • Binder C, Cvetkovski F, Sellberg F, Berg S, Visbal HP, Sachs DH, Berglund E, Berglund D . CD2 immunobiology. Frontiers in Immunology In Press


  • Podesta MA, Binder C, Sellberg F, DeWolf S, Shonts B, Ho SH, Obradovic A, Waffarn E, Danzl N, Berglund D , Sykes M. Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro. American Journal of Transplantation 2020;20(1):88-100


  • Strandberg G, Sellberg F, Sommar P, Ronaghi M, Lubenow N, Knutson F, Berglund D . Standardizing the freeze-thaw preparation of growth factors from platelet lysate. Transfusion 2017;57(4):1058-65