Key publications

Concept of thromboinflammation

Moberg, L., Johansson, H., Luknius, A, Berne, C., Foss, A., Källen, R., Østraat, Ø, Salmela, K., Tibell, A., Tufveson, G., Elgue, G., Ekdahl, K N., Larsson, R., Korsgren, O., Nilsson, B. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002; 360:2039-2045

Özmen, L., Ekdahl, K N. Elgue, G., Larsson, R., Korsgren, O., Nilsson, B. Inhibition of thrombin with Melagatran abrogates instant blood mediated islet reaction (IBMIR) in vitro: Possible application in clinical allogeneic pacreatic islet transplantation. Diabetes 2002; 51: 1779-1784

Goto M, Tjernberg J, Dufrane D, Elgue G, Brandhorst D, Ekdahl, K N. Brandhorst H, Wennberg L, Kurokawa Y, Satomi S, Lambris JD, Gianello P, Korsgren O, Nilsson B. Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation 2008; 15(4): 225-234

Nilsson, B., Ekdahl, K N., Korsgren, O. Control of IBMIR (Instant Blood-Mediated Inflammatory Reaction) to improve islets of Langerhans engraftment. Current Opinion in Organ Transplantation, 2011;16(6):620-6

Biglarnia, A-R, Nilsson, B, Ekdahl, K N., Tufveson, G, Nilsson, T, Wadström, J Desenzitation Protocol with Antigen-Specific Immunoadsorption Interferes with Complement in ABO Incompatible Renal Transplantation. Transplantation 2012; 93(1):87-92

Nilsson, B., Teramura, Y, Ekdahl, K N. The role and regulation of complement activation as part of the thromboinflammation elicited in cell therapies. Mol Immunol 2014; 61(2):185-190

Teramura, Y, Asif, S, Ekdahl, KN, Nilsson, B. Cell surface engineering for regulation of immune reactions in cell therapy. In ”Immune Responses to Biosurfaces” Adv Exp Med Biol. 2015;865:189-209.

Biglarnia, A-R, Ekdahl, KN, Nilsson, B. Complement interception across humoral incompatibility in solid organ transplantation – a clinical perspective. In ”Immune Responses to Biosurfaces” Adv Exp Med Biol. 2015;865:211-33.

Ekdahl, KN, Teramura, Y, Hamad, OA, Asif, S, Dürhkop, C, Fromell, K, Gustafson, E, Hong, J, Kozarcanin, H, Magnusson, PU, Huber-Lang, M, Garred, P, Nilsson, B.  Dangerous liaisons: Complement, coagulation, and kallikrein/kinin crosstalk act as a linchpin in the events leading to thromboinflammation. Immunological Reviews  2016 Nov;274(1):245-269.

Ekdahl, KN, Soveri, I, Hilborn, J, Fellström, B, Nilsson, B . Cardiovascular disease in haemodialysis : role of the intravascular innate immune system. Nat Rev Nephrol. 2017 May;13(5):285-296. 

Biglarnia, A-R, Huber-Lang, M, Mohlin, C, Ekdahl, KN, Nilsson, B.  The multifaceted role of complement in kidney transplantation. Nat Rev Nephrol  2018 Dec;14(12):767-781.

Characterizing the product and other cell binding compounds

Teramura Y, Kaneda Y, Iwata H. Islet-encapsulation in ultra-thin layer-by-layer membranes of poly(vinyl alcohol) anchored to poly(ethylene glycol)-lipids in the cell membrane. Biomaterials. 2007 Nov;28(32):4818-25. Epub 2007 Aug 14.

Teramura Y, Iwata H. Surface modification of islets with PEG lipid for improvement of graft survival in intraportaltransplantation. Transplantation. 2009 Sep 15;88(5):624-30.

Nilsson, PH, Ekdahl, K N. Magnusson, PU, Ricklin, D, Iwata, H, Lambris, JD, Hong, J, Nilsson, B, Teramura, Y. Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating. Biomaterials 2013;34(4):985-994

Asif, S, Ekdahl, KN, Fromell, K, Gustafson, E, Le Blanc, K, Nilsson, B, Teramura, Y. Heparinization of cell surfaces with short peptide-conjugated PEG-lipid regulates thromboinflammation in transplantation of human MSCs and hepatocytes. Acta Biomater. 2016 35. 194-205

Teramura, Y, Asif, S, Ekdahl, KN,  Gustafson, E, Nilsson, B. Cell adhesion induced using surface modification with cell-penetrating peptide-conjugated PEG-lipid: A new cell glue for 3D cell-based structures. ACS Appl Mater Interfaces. 2017 9(1):244-254.

Noiri, M, Asawa, K, Okada, N, Kodama, T, Murayama, Y, Inoue, Y, Ishihara, K, , Ekdahl, KN, Nilsson, B, Teramura, Y. Cell surface engineering of human MSC with short peptide-PEG-lipid for homing to activated endothelium to improve therapeutic effects in stroke. J Biomed Mater Res A. 2019 Aug;107(8):1779-1792.

Alireza Biglarnia cutting edge publications

Berglund D, Karlsson M, Biglarnia AR, Lorant T, Tufveson G, Korsgren O, Carlsson B. Obtaining regulatory T cells from uraemic patients awaiting kidney transplantation for use in clinical trials. Clin Exp Immunol. 2013 Aug;173(2):310-22.

Berglund D, Bergqvist D, Lundqvist E, Magnusson A, Sedigh A, Bäckman L, Biglarnia AR.  Vascular reconstruction using allogeneic homografts in a renal transplant patient with pseudoaneurysm and infected vascular prosthesis. Transplantation. 2012 Feb 27;93(4):e15-6.

Berglund D, Bengtsson M, Biglarnia A, Berglund E, Yamamoto S, von Zur-Mühlen B, Lorant T, Tufveson G. Screening of mortality in transplant patients using an assay for immune function. Transpl Immunol. 2011 May;24(4):246-50.

Kristina N Ekdahl cutting edge publications

Ekdahl, KN, Huang, S, Nilsson, B, Teramura, Y. Complement inhibition in biomaterial- and biosurface-induced thromboinflammation. Seminars in Immunology, 2016; 28(3); 268-277

Harboe, M, Johnson, C, Nymo, S, Ekholt, K, Schjalm, C, Lindstad, JK, Pharo, A, Hellerud, BC, Ekdahl, KN , Mollnes, TE, Nilsson, PH. Properdin binding to complement activating surfaces depends on initial C3b deposition. PNAS 2017 Jan 24;114(4):E534-E539.

Eriksson, O, Mohlin, C, Nilsson, B, Ekdahl, KN. Platelets and Immune Responses During Thromboinflammation. The human platelet as an innate immunity cell: Interaction between activated platelets and the complement system. Front Immunol. 2019 Jul 10;10:1590. doi: 10.3389/fimmu.2019.01590. eCollection 2019.

Marianne Jensen-Waern cutting edge publications

Gröndahl, G., Johannisson, A. Jensen-Waern, M., Ekdahl, K N. Opsonization of yeast cells with equine C3 and IgG. Vet Immunol Immunopathol 2001;6425:1-15

Rydén A, Manell E, Biglarnia A, Hedenqvist P, Strandberg G, Ley C, Hansson K, Nyman G,  Jensen-Waern M. Nursing and training of pigs used in renal transplantation studies. Lab Anim. 2019 Oct 24:23677219879169.

Hedenqvist P, Trbakov A, Mellgren T, Öhman-Mägi C, Hammarström Johansson P, Manell E, Ekman S, Ley C, Jensen-Waern M , Thor A .The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits. PloS One 2020; in press.

Bo Nilsson cutting edge publications

Janssen, B J C, Huizinga, E G, Raaijmakers, H C A, Roos, A, Daha, M R, Ekdahl, K N. Nilsson B , Gros, P Structures of complement component C3 provide insights into the function and evolution of immunity. Nature 2005;437; 505-511

Dührkop, C, Leneweit, G, Heyder, C, Fromell, K, Edwards, K, Ekdahl, KN, Nilsson, B. Development and characterization of an innovative heparin coating to stabilize and protect liposomes against adverse immune reactions.  Colloids and Surfaces B: Biointerfaces 2016 Feb 8;141:576-583

Fromell, K, Adler, A, Åman, A, Manivel, VA, Huang, S, Dührkop, C, Sandholm, K, Ekdahl, KN, Nilsson, B. Assessement of the role of C3(H2O) in the alternative pathway. 2020. Frontiers in immunology in press

Yuji Teramura cutting edge publications

Teramura Y, Iwata H. Bioartificial pancreas microencapsulation and conformal coating of islet of Langerhans Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):827-40.

Teramura Y, Chen H, Kawamoto T, Iwata H. Control of cell attachment through polyDNA hybridization. Biomaterials. 2010 Mar;31(8):2229-35.

Teramura Y, Iwata H. Improvement of graft survival by surface modification with poly(ethylene glycol)-lipid and urokinase in intraportal islet transplantation. Transplantation. 2011 Feb 15;91(3):271-8.

David Berglund cutting edge publications

Binder C, Cvetkovski F, Sellberg F, Berg S, Visbal HP, Sachs DH, Berglund E, Berglund D . CD2 immunobiology. Frontiers in Immunology In Press

Podesta MA, Binder C, Sellberg F, DeWolf S, Shonts B, Ho SH, Obradovic A, Waffarn E, Danzl N, Berglund D , Sykes M. Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro. American Journal of Transplantation 2020;20(1):88-100

Strandberg G, Sellberg F, Sommar P, Ronaghi M, Lubenow N, Knutson F, Berglund D . Standardizing the freeze-thaw preparation of growth factors from platelet lysate. Transfusion 2017;57(4):1058-65