Moberg, L., Johansson, H., Luknius, A, Berne, C., Foss, A., Källen, R., Østraat, Ø, Salmela, K., Tibell, A., Tufveson, G., Elgue, G., Ekdahl, K N., Larsson, R., Korsgren, O., Nilsson, B. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002; 360:2039-2045
Özmen, L., Ekdahl, K N. Elgue, G., Larsson, R., Korsgren, O., Nilsson, B. Inhibition of thrombin with Melagatran abrogates instant blood mediated islet reaction (IBMIR) in vitro: Possible application in clinical allogeneic pacreatic islet transplantation. Diabetes 2002; 51: 1779-1784
Goto M, Tjernberg J, Dufrane D, Elgue G, Brandhorst D, Ekdahl, K N. Brandhorst H, Wennberg L, Kurokawa Y, Satomi S, Lambris JD, Gianello P, Korsgren O, Nilsson B. Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation 2008; 15(4): 225-234
Nilsson, B., Ekdahl, K N., Korsgren, O. Control of IBMIR (Instant Blood-Mediated Inflammatory Reaction) to improve islets of Langerhans engraftment. Current Opinion in Organ Transplantation, 2011;16(6):620-6
Biglarnia, A-R, Nilsson, B, Ekdahl, K N., Tufveson, G, Nilsson, T, Wadström, J Desenzitation Protocol with Antigen-Specific Immunoadsorption Interferes with Complement in ABO Incompatible Renal Transplantation. Transplantation 2012; 93(1):87-92
Nilsson, B., Teramura, Y, Ekdahl, K N. The role and regulation of complement activation as part of the thromboinflammation elicited in cell therapies. Mol Immunol 2014; 61(2):185-190
Teramura, Y, Asif, S, Ekdahl, KN, Nilsson, B. Cell surface engineering for regulation of immune reactions in cell therapy. In ”Immune Responses to Biosurfaces” Adv Exp Med Biol. 2015;865:189-209.
Biglarnia, A-R, Ekdahl, KN, Nilsson, B. Complement interception across humoral incompatibility in solid organ transplantation – a clinical perspective. In ”Immune Responses to Biosurfaces” Adv Exp Med Biol. 2015;865:211-33.
Ekdahl, KN, Teramura, Y, Hamad, OA, Asif, S, Dürhkop, C, Fromell, K, Gustafson, E, Hong, J, Kozarcanin, H, Magnusson, PU, Huber-Lang, M, Garred, P, Nilsson, B. Dangerous liaisons: Complement, coagulation, and kallikrein/kinin crosstalk act as a linchpin in the events leading to thromboinflammation. Immunological Reviews 2016 Nov;274(1):245-269.
Ekdahl, KN, Soveri, I, Hilborn, J, Fellström, B, Nilsson, B . Cardiovascular disease in haemodialysis : role of the intravascular innate immune system. Nat Rev Nephrol. 2017 May;13(5):285-296.
Biglarnia, A-R, Huber-Lang, M, Mohlin, C, Ekdahl, KN, Nilsson, B. The multifaceted role of complement in kidney transplantation. Nat Rev Nephrol 2018 Dec;14(12):767-781.
Characterizing the product and other cell binding compounds
Teramura, Y, Iwata, H. Cell surface modification with polymers for biomedical studies, Soft Matter. 6 (6), 1081-1091.
Teramura Y, Kaneda Y, Iwata H. Islet-encapsulation in ultra-thin layer-by-layer membranes of poly(vinyl alcohol) anchored to poly(ethylene glycol)-lipids in the cell membrane. Biomaterials. 2007 Nov;28(32):4818-25. Epub 2007 Aug 14.
Teramura Y, Iwata H. Surface modification of islets with PEG lipid for improvement of graft survival in intraportaltransplantation. Transplantation. 2009 Sep 15;88(5):624-30.
Nilsson, PH, Ekdahl, K N. Magnusson, PU, Ricklin, D, Iwata, H, Lambris, JD, Hong, J, Nilsson, B, Teramura, Y. Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating. Biomaterials 2013;34(4):985-994
Asif, S, Ekdahl, KN, Fromell, K, Gustafson, E, Le Blanc, K, Nilsson, B, Teramura, Y. Heparinization of cell surfaces with short peptide-conjugated PEG-lipid regulates thromboinflammation in transplantation of human MSCs and hepatocytes. Acta Biomater. 2016 35. 194-205
Teramura, Y, Asif, S, Ekdahl, KN, Gustafson, E, Nilsson, B. Cell adhesion induced using surface modification with cell-penetrating peptide-conjugated PEG-lipid: A new cell glue for 3D cell-based structures. ACS Appl Mater Interfaces. 2017 9(1):244-254.
Noiri, M, Asawa, K, Okada, N, Kodama, T, Murayama, Y, Inoue, Y, Ishihara, K, , Ekdahl, KN, Nilsson, B, Teramura, Y. Cell surface engineering of human MSC with short peptide-PEG-lipid for homing to activated endothelium to improve therapeutic effects in stroke. J Biomed Mater Res A. 2019 Aug;107(8):1779-1792.
Asawa, K, Ishihara, K, Ekdahl, K.N, Nilsson, B, Teramura, Y. Cell surface functionalization with heparin-conjugated lipid to suppress blood activation. Advanced Functional Materials 31 (11), 2008167
Alireza Biglarnia’s Key Publications
Berglund D, Karlsson M, Biglarnia AR, Lorant T, Tufveson G, Korsgren O, Carlsson B. Obtaining regulatory T cells from uraemic patients awaiting kidney transplantation for use in clinical trials. Clin Exp Immunol. 2013 Aug;173(2):310-22.
Berglund D, Bergqvist D, Lundqvist E, Magnusson A, Sedigh A, Bäckman L, Biglarnia AR. Vascular reconstruction using allogeneic homografts in a renal transplant patient with pseudoaneurysm and infected vascular prosthesis. Transplantation. 2012 Feb 27;93(4):e15-6.
Berglund D, Bengtsson M, Biglarnia A, Berglund E, Yamamoto S, von Zur-Mühlen B, Lorant T, Tufveson G. Screening of mortality in transplant patients using an assay for immune function. Transpl Immunol. 2011 May;24(4):246-50.
Kristina N Ekdahl’s Key Publications
Ekdahl, KN, Huang, S, Nilsson, B, Teramura, Y. Complement inhibition in biomaterial- and biosurface-induced thromboinflammation. Seminars in Immunology, 2016; 28(3); 268-277
Harboe, M, Johnson, C, Nymo, S, Ekholt, K, Schjalm, C, Lindstad, JK, Pharo, A, Hellerud, BC, Ekdahl, KN , Mollnes, TE, Nilsson, PH. Properdin binding to complement activating surfaces depends on initial C3b deposition. PNAS 2017 Jan 24;114(4):E534-E539.
Eriksson, O, Mohlin, C, Nilsson, B, Ekdahl, KN. Platelets and Immune Responses During Thromboinflammation. The human platelet as an innate immunity cell: Interaction between activated platelets and the complement system. Front Immunol. 2019 Jul 10;10:1590. doi: 10.3389/fimmu.2019.01590. eCollection 2019.
Marianne Jensen-Waern’s Key Publications
Gröndahl, G., Johannisson, A. Jensen-Waern, M., Ekdahl, K N. Opsonization of yeast cells with equine C3 and IgG. Vet Immunol Immunopathol 2001;6425:1-15
Rydén A, Manell E, Biglarnia A, Hedenqvist P, Strandberg G, Ley C, Hansson K, Nyman G, Jensen-Waern M. Nursing and training of pigs used in renal transplantation studies. Lab Anim. 2019 Oct 24:23677219879169.
Hedenqvist P, Trbakov A, Mellgren T, Öhman-Mägi C, Hammarström Johansson P, Manell E, Ekman S, Ley C, Jensen-Waern M, Thor A .The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits. PloS One 2020; May 21;15(5):e0233530. doi: 10.1371/journal.pone.0233530. eCollection 2020.PMID: 32437406
Manell E, Puuvuori E, Svensson A, Velykian I, Hedenqvist P, Hulsart G, Holst J, Jensen-Waern M, Eriksson O. “Exploring the GLP-1 – GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography. BMJ Open Diabetes Research & Care, 2021; Apr;9(1):e002083. doi: 10.1136/bmjdrc-2020-002083.PMID: 33903116
Bo Nilsson’s publications Key Publications
Janssen, B J C, Huizinga, E G, Raaijmakers, H C A, Roos, A, Daha, M R, Ekdahl, K N. Nilsson B , Gros, P Structures of complement component C3 provide insights into the function and evolution of immunity. Nature 2005;437; 505-511
Dührkop, C, Leneweit, G, Heyder, C, Fromell, K, Edwards, K, Ekdahl, KN, Nilsson, B. Development and characterization of an innovative heparin coating to stabilize and protect liposomes against adverse immune reactions. Colloids and Surfaces B: Biointerfaces 2016 Feb 8;141:576-583
Fromell, K, Adler, A, Åman, A, Manivel, VA, Huang, S, Dührkop, C, Sandholm, K, Ekdahl, KN, Nilsson, B. Assessement of the role of C3(H2O) in the alternative pathway. 2020. Frontiers in immunology in press
Yuji Teramura’s Key Publications
Teramura Y, Iwata H. Bioartificial pancreas microencapsulation and conformal coating of islet of Langerhans Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):827-40.
Teramura Y, Chen H, Kawamoto T, Iwata H. Control of cell attachment through polyDNA hybridization. Biomaterials. 2010 Mar;31(8):2229-35.
Teramura Y, Iwata H. Improvement of graft survival by surface modification with poly(ethylene glycol)-lipid and urokinase in intraportal islet transplantation. Transplantation. 2011 Feb 15;91(3):271-8.
Teramura, Y. Ekdahl, K.N, Nilsson, B, Fromell, K, Ishihara, K. Potential of cell surface engineering with biocompatible polymers for biomedical applications. Langmuir. 2020 Sep 36 (41), 12088-12106.
David Berglund’s Key Publications
Binder C, Cvetkovski F, Sellberg F, Berg S, Visbal HP, Sachs DH, Berglund E, Berglund D . CD2 immunobiology. Frontiers in Immunology In Press
Podesta MA, Binder C, Sellberg F, DeWolf S, Shonts B, Ho SH, Obradovic A, Waffarn E, Danzl N, Berglund D , Sykes M. Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro. American Journal of Transplantation 2020;20(1):88-100
Strandberg G, Sellberg F, Sommar P, Ronaghi M, Lubenow N, Knutson F, Berglund D . Standardizing the freeze-thaw preparation of growth factors from platelet lysate. Transfusion 2017;57(4):1058-65